Association of Vitamin D Deficiency with Coronary Artery Disease
Published: September 1, 2016 | DOI: https://doi.org/10.7860/JCDR/2016/22718.8526
Deba Prasad Dhibar, Yash Paul Sharma, Sanjay Kumar Bhadada, Naresh Sachdeva, Kamal Kant Sahu
1. Senior Resident, Department of Internal Medicine, PGIMER, Chandigarh, India.
2. Professor & Head, Department of Cardiology, PGIMER, Chandigarh, India.
3. Additional Professor, Department of Endocrinology, PGIMER, Chandigarh, India.
4. Associate Professor, Department of Endocrinology, PGIMER, Chandigarh, India.
5. Senior Resident, Department of Internal Medicine, PGIMER, Chandigarh, India.
Correspondence
Dr. Deba Prasad Dhibar,
Senior Resident, Department of Internal Medicine, PGIMER, Chandigarh, India.
E-mail: drdeba_prasad@yahoo.co.in
Introduction: Coronary Artery Disease (CAD) is a major global health problem. Recent studies demonstrated that lower vitamin D level (<30ng/ml) is associated with higher blood pressure and directly or indirectly with CAD, due to vascular endothelial damage. However the results are inconsistent.
Aim: To find the association of vitamin D deficiency with CAD
Materials and Methods: In this cross-sectional observational study, serum vitamin D level was measured in 315 patients who underwent coronary angiography.
Result: The mean (±SD) vitamin D was 13.40ng/ml (±10.40). However, the patients with normal coronary artery had much lower mean vitamin D (11.30ng/ml±9.50) as compared to the patients with CAD (14.10ng/ml±10.70). The mean (±SD) vitamin D levels were 19.00ng/ml (±16.50), 14.10ng/ml (±11.10) and 13.20ng/ml (±8.80) in patients with CAD with 50%-70%, >70%-90% and >90% stenosis respectively (p= 0.46) and 15.20ng/ml (±13.00), 15.50ng/ml (±11.30) and 11.80ng/ml (±7.00) in patients with CAD with single, double and triple vessels disease respectively (p= 0.14). The frequency of vitamin D deficiency were 66.70%, 83.20 % and 83.10% in patients with CAD with 50% -70%, >70%-90% and >90% stenosis respectively and 81.40%, 80.00% and 83.50% in patients with single, double and triple vessel disease respectively, as compared to 89.30% in patients with normal coronary artery (p= 0.41 and 0.075). So, all the study groups of CAD had low serum vitamin D level and high frequency of vitamin D deficiency, which was statistically insignificant.
Conclusion: Prevalence of vitamin D deficiency is very high in CAD, but it does not correlate with the angiographic severity of CAD.
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